Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest
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منابع مشابه
Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest
Stratified epithelium displays an equilibrium between proliferation and cell cycle arrest, a balance that is disrupted in basal cell carcinoma (BCC). Sonic hedgehog (Shh) pathway activation appears sufficient to induce BCC, however, the way it does so is unknown. Shh-induced epidermal hyperplasia is accompanied by continued cell proliferation in normally growth arrested suprabasal cells in vivo...
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Are there related proteins? Lots. In mammals, Sonic is related to two other hedgehogs: Indian and Desert. When expressed appropriately, the three proteins can substitute for one another but they do have unique functions: Desert hedgehog is needed for spermatogenesis and Indian hedgehog regulates cartilage differentiation. In the zebrafish, Sonic is related to Tiggywinkle hedgehog — which is tho...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1999
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.147.1.71